[Development of lecithinized superoxide dismutase as a drug for IPF].

نویسنده

  • Tohru Mizushima
چکیده

Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are thought to involve lung injury induced by reactive oxygen species (ROS), in particular superoxide anion. The enzyme, superoxide dismutase (SOD) catalyses the dismutation of superoxide anion to hydrogen peroxide. Lecithinized SOD (PC-SOD) has overcome a number of previous clinical limitations of SOD, including low tissue affinity and low stability in plasma. Recent animal studies suggest that PC-SOD is effective for the treatment of IPF and COPD. We are now performing the clinical study of PC-SOD for IPF patients.

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عنوان ژورنال:
  • Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

دوره 134 1  شماره 

صفحات  -

تاریخ انتشار 2014